- Sackboy: A Big Adventure (1)
- Saints Row IV (2)
- Sally Face (2)
- Samurai Shodown (5)
- Sea of Thieves (36)
- Sekiro: Shadows Die Twice (5)
- Shadow of the Colossus (23)
- Shin Megami Tensei (1)
- Shovel Knight (9)
- Silent Hill (2)
- Silent Hill 2 (7)
- Silent Hill 3 (13)
- Skylanders: SuperChargers (2)
- Sly 3: Honor Among Thieves (2)
- Sly Cooper: Thieves in Time (2)
- Smite (4)
- Sonic Generations (1)
- Sonic the Hedgehog (48)
- Soulcalibur (1)
- Soulcalibur II (9)
- Soulcalibur VI (1)
- South Park: The Fractured But Whole (5)
- Space Invaders (2)
- Spider-Man (20)
- Spider-Man: Miles Morales (6)
- Splatoon (15)
- Splatoon 2 (6)
- Splatterhouse (2)
- Splinter Cell (1)
- Splinter Cell: Blacklist (4)
- Splinter Cell: Conviction (2)
- Spyro the Dragon (15)
- Star Citizen (8)
- Star Wars Battlefront II (2)
- Star Wars Jedi: Fallen Order (1)
- Star Wars Knights of the Old Republic II: The Sith Lords (1)
- Star Wars: Bounty Hunter (1)
- Star Wars: Squadrons (1)
- StarCraft (7)
- StarCraft II: Wings of Liberty (5)
- Starfox (2)
- State of Decay 2 (1)
- Street Fighter (37)
- Street Fighter Alpha (1)
- Street Fighter Alpha 2 (7)
- Street Fighter Alpha 3 (3)
- Street Fighter II (9)
- Street Fighter II, Ultra: The Final Challengers (8)
- Street Fighter II: Champion Edition (1)
- Street Fighter III (3)
- Street Fighter III: 2nd Impact (1)
- Street Fighter IV (13)
- Street Fighter V (38)
- Streets of Rage 4 (1)
- Stronghold (1)
- Super Mario 3D World (1)
- Super Mario Bros (43)
- Super Mario Bros 3 (4)
- Super Mario Kart (1)
- Super Mario Odyssey (4)
- Super Mario World (1)
- Super Meat Boy (4)
- Super Smash Bros (62)
- Super Smash Bros Ultimate (3)
- Super Street Fighter II (3)
- Super Street Fighter II Turbo (3)
- Super Street Fighter IV (2)
- Sword Art Online: Fatal Bullet (1)
- System Shock (1)
